In the early 2000s, the Erin Devine Gallery was located in a former firehouse in the arts district along Market Street in Louisville, now known as NuLu.  The commercial gallery operated for five years before Erin left Louisville to pursue a doctorate.

Exhibiting works by established and emerging, local and international artists working in photography, installation, sculpture, and painting, it was a founding space of both the First Friday Gallery Hop and the Louisville Photo Biennial, as well as establishing an international exchange between Louisville and Dublin, Ireland.